On the 2022 World Chagas Disease Day, the Health Surveillance Secretariat of the Brazilian Ministry of Health published a special epidemiological bulletin on chronic Chagas Disease. Territorialization and Vulnerability are the words that guide the analysis of chronic Chagas disease in this continental country. The Brazilian Ministry of Health is a co-financier of the CUIDA Chagas project, as well as a strategic partner for the implementation in Brazilian territories.